Lipid A Salmonella (Highly Pure)

Product Description 4.8/5 - (20 votes) Lipid A (Salmonella, Highly Pure) Catalog number: MDP0894 Name: 2-Deoxy-6-O-{2-Deoxy-2-[(R)-3-(Dodecanoyloxy)Tetradecanoylamino]-3-O-[(R)-3-(Tetradecanoyloxy)Tetradecanoyl]-beta-D-Glucopyranosyl}-2-[(R)-3-(Hexadecanoyloxy)Tetradecanoylamino]-3-O-[(R)-3-Hydroxytetradecanoyl]-alpha-D-Glucopyranose 1,4′-Diphosphate Other name(s): Lipid A (Salmonella) Molecular Formula: C110H208N2O26P2 Molecular Mass: 2036.8 CAS #: 100742-61-8 Storage Temperature: -20C Indication for Use: This product if for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use. Safety: User must review the Safety Data Sheet (SDS) provided with this product. In addition, this product should not be ingested, inhaled, swallowed or put in contact with eyes, skin or clothes. References: 1: Gao J, Guo Z. Progress in the synthesis and biological evaluation of lipid A and its derivatives. Med Res Rev. 2018 Mar;38(2):556-601. 2: Wang X, Quinn PJ, Yan A. Kdo2 -lipid A: structural diversity and impact on immunopharmacology. Biol Rev Camb Philos Soc. 2015 May;90(2):408-27. 3: Molinaro A, Holst O, Di Lorenzo F, Callaghan M, Nurisso A, D’Errico G, Zamyatina A, Peri F, Berisio R, Jerala R, Jiménez-Barbero J, Silipo A, Martín- Santamaría S. Chemistry of lipid A: at the heart of innate immunity. Chemistry. 2015 Jan 7;21(2):500-19. doi: 10.1002/chem.201403923. Epub 2014 Oct 29. PMID: 25353096. 4: Verpalen ECJM, Brouwer AJ, Boons GJ. Synthesis of monophosphoryl lipid A using 2-naphtylmethyl ethers as permanent protecting groups. Carbohydr Res. 2020 Dec;498:108152. 5: Xiao X, Sankaranarayanan K, Khosla C. Biosynthesis and structure-activity relationships of the lipid a family of glycolipids. Curr Opin Chem Biol. 2017 Oct;40:127-137. 6: Scott AJ, Oyler BL, Goodlett DR, Ernst RK. Lipid A structural modifications in extreme conditions and identification of unique modifying enzymes to define the Toll-like receptor 4 structure-activity relationship. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Nov;1862(11):1439-1450. 7: Nelson N, Opene B, Ernst RK, Schwartz DK. Antimicrobial peptide activity is anticorrelated with lipid a leaflet affinity. PLoS One. 2020 Nov 30;15(11):e0242907. 8: Fujimoto Y, Adachi Y, Akamatsu M, Fukase Y, Kataoka M, Suda Y, Fukase K, Kusumoto S. Synthesis of lipid A and its analogues for investigation of the structural basis for their bioactivity. J Endotoxin Res. 2005;11(6):341-7. 9: Di Lorenzo F, Crisafi F, La Cono V, Yakimov MM, Molinaro A, Silipo A. The Structure of the Lipid A of Gram-Negative Cold-Adapted Bacteria Isolated from Antarctic Environments. Mar Drugs. 2020 Nov 26;18(12):592. 10: Cheng R, Fontana F, Xiao J, Liu Z, Figueiredo P, Shahbazi MA, Wang S, Jin J, Torrieri G, Hirvonen JT, Zhang H, Chen T, Cui W, Lu Y, Santos HA. Recombination Monophosphoryl Lipid_A-Derived Vacosome for the Development of Preventive Cancer Vaccines. ACS Appl Mater Interfaces. 2020 Oct 7;12(40):44554-44562. Products Related to Lipid A (Salmonella): Peptides