Xanthine Oxidase Grade II (Lyophilized Powder)

Product Description 4.9/5 - (8 votes) Xanthine Oxidase Grade II. Catalog # P2010006 Size 100 U and bulk Unit Definition Amount of enzyme that produces one micromole of uric acid per minute at pH 7.5 and 25 °C. Molecular Weight 160 kDa Specific Activity 16 U/mg Purity Uricase, phosphatase < 0.001% Storage -20°C. Avoid repeated freeze/thaw cycles. Supplied as Brow-red lyophilized powder Keywords Xanthine oxidase   References Xanthine oxidase of Acinetobacter calcoaceticus RL2-M4: Production, purification and characterization. Monika, Sharma NK, Thakur N, Sheetal, Savitri, Bhalla TC. Protein Expr Purif. 2019 Aug;160:36-44. Xanthine Oxidase and its Role as Target in Cardiovascular Disease: Cardiovascular Protection by Enzyme Inhibition? Schuchardt M, Herrmann J, Tolle M, van der Giet M. Curr Pharm Des. 2017;23(23):3391-3404. Xanthine oxidase inhibitory activity of new pyrrole carboxamide derivatives: In vitro and in silico studies. Kıbrız Ä°E, Saçmacı M, Yıldırım Ä°, Abbas Ali Noma S, TaÅŸkın Tok T, AteÅŸ B. Arch Pharm (Weinheim). 2018 Oct;351(10):e1800165. Design, synthesis and biological evaluation of 1-hydroxy-2-phenyl-4-pyridyl-1H-imidazole derivatives as xanthineoxidase inhibitors. Zhang T, Lv Y, Lei Y, Liu D, Feng Y, Zhao J, Chen S, Meng F, Wang S. Eur J Med Chem. 2018 Feb 25;146:668-677. Novel XanthineOxidase (XO) inhibitory phenylindanes produced by thermal reaction of caffeic acid. Fukuyama Y, Hidaka K, Masuda A, Masuda T. Biosci Biotechnol Biochem. 2018 Oct;82(10):1825-1828. Design, synthesis, and biological evaluation of 5-(4-(pyridin-4-yl)-1H-1,2,3-triazol-1-yl)benzonitrile derivatives as xanthineoxidase inhibitors. Zhang TJ, Li SY, Zhang Y, Wu QX, Meng FH. Chem Biol Drug Des. 2018 Feb;91(2):526-533. In-silico Design and ADMET Studies of Natural Compounds as Inhibitors of XanthineOxidase (XO) Enzyme. Malik N, Dhiman P, Khatkar A. Curr Drug Metab. 2017;18(6):577-593. Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate. Yamaguchi Y, Matsumura T, Ichida K, Okamoto K, Nishino T. J Biochem. 2007 Apr;141(4):513-24.