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Product Description 5/5 - (2 votes) CDK5 Substrate – (5-TMR) labeled Catalog number: B2019514 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 1 mg Molecular Weight or Concentration: 1551 Supplied as: Powder Applications: a molecular tool for various biochemical applications Storage: -20°C Keywords: 5-TMR-PKTPKKAKKL Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. References: 1: He Y, Pan S, Xu M, He R, Huang W, Song P, Huang J, Zhang HT, Hu Y. Adeno-associated virus 9-mediated Cdk5 inhibitory peptide reverses pathologic changes and behavioral deficits in the Alzheimer’s disease mouse model FASEB J. 2017 Aug;31(8):3383-3392. 2: Su SC, Seo J, Pan JQ, Samuels BA, Rudenko A, Ericsson M, Neve RL, Yue DT, Tsai LH. Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5 Neuron. 2012 Aug 23;75(4):675-87. 3: Cho DH, Seo J, Park JH, Jo C, Choi YJ, Soh JW, Jo I. Cyclin-dependent kinase 5 phosphorylates endothelial nitric oxide synthase at serine 116 Hypertension. 2010 Feb;55(2):345-52. 4: Cruz JC, Tseng HC, Goldman JA, Shih H, Tsai LH. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles Neuron. 2003 Oct 30;40(3):471-83. 5: Nguyen MD, Larivière RC, Julien JP. Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions Neuron. 2001 Apr;30(1):135-47. 6: Seeburg DP, Feliu-Mojer M, Gaiottino J, Pak DT, Sheng M. Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity Neuron. 2008 May 22;58(4):571-83. 7: Zambrano CA, Egaña JT, Núñez MT, Maccioni RB, González-Billault C. Oxidative stress promotes tau dephosphorylation in neuronal cells: the roles of cdk5 and PP1 Free Radic Biol Med. 2004 Jun 1;36(11):1393-402. 8: Cazares VA, Njus MM, Manly A, Saldate JJ, Subramani A, Ben-Simon Y, Sutton MA, Ashery U, Stuenkel EL. Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn J Neurosci. 2016 Nov 2;36(44):11208-11222. 9: Yeh CW, Hsu LS. Zebrafish diras1 Promoted Neurite Outgrowth in Neuro-2a Cells and Maintained Trigeminal Ganglion Neurons In Vivo via Rac1-Dependent Pathway Mol Neurobiol. 2016 Dec;53(10):6594-6607. 10: Nehmé R, Nehmé H, Roux G, Destandau E, Claude B, Morin P. Capillary electrophoresis as a novel technique for screening natural flavonoids as kinase inhibitors J Chromatogr A. 2013 Nov 29;1318:257-64. Products Related to CDK5 Substrate – (5-TMR) labeled can be found at Substrates
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